Berman was a co-founder of the Protein Data Bank (PDB) that is an archive of information about the structures of proteins, nucleic acids, and complex assemblies and was the Director of the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) from 1998-2014. As a structural biologist, she has always been fascinated by the architectures and functions of biological molecules and has also been inspired by their beauty. However, over the years she realized how difficult it is to communicate this to a broader audience. In 2015, she embarked on a new project to use film in order to educate others about the integral role played by molecules in health and disease. She collaborated with animators and documentary film makers to produce Target Zero, which won the prize for Best Educational Media at the 2017 Raw Science Film Festival. She is currently the scientific advisor to World in a Cell.